The input formate
The PPML support arbitrary mutation gene in PAH, include compound heterozygous and homozygote.
1 : The input allelic mutation, PPML accepted the mutation's format as 'c.728G>A'.
2 : The formate example of input mutations.
3 : Submit for the prediction of PKU phenotype.
Tips: the PPML only accept the mutations in PAH gene.
Prediction result
The Phenotype prediction by machine learning method.
1 : Input: The allelic mutations were input.
2 : Record: Allelic mutations associate with PKU phenotype by case database.
3 : Prediction: PKU phenotype predicted by machine learning method.
4 : Links Info: The hyperlinks of allelic mutations to other important database.
Tips: In the link information, it does not find the corresponding mutation information in another database, it does not click.
Phenotype
The classification of PKU phenotype allelic mutations in case database.
1 : The classification of PKU phenotype by blood PHE values.
2 : Classification of phenotypes corresponding to different PHE value ranges.
Distribution
The distribution of allelic phenotype in case database.
Statistic
The statistic of PHE value in case database that contain maximum PHE, Minimum PHE and mean PHE.
The input formate
The PPML network search support arbitrary mutation gene in PAH.
1 : The input mutations in PAH gene
2 : The formate example of input mutations.
3 : Submit for the prediction of PKU phenotype.
Search result
The Phenotype linkage network in case database.
1 : Input: The input mutation.
2 : Network linkage: The mutations associate with PKU phenotype linkages informations.
4 : Links Info: The hyperlinks of mutation to other important database.
linkage network
The linkage network for PKU phenotype in case database.
1 : linkage network
2 : Calculate the hub phenotype of input mutation.
Mutation table
The mutation table with blood PHE and phenotype information in case database.
ID : Case ID
Allele 1 : The mutation in PAH genes.
Allele 2 : The mutation in PAH genes.
Blood Phe : The case blood PHE value.
Phenotype : PKU phenotype classified by PHE values.